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Protein Databases> Motifs NCBI
ExPASy InterPro
Motifs
- Motifs are narrowly defined as short, highly conserved regions within domains.
- Motifs are considered required, but not sufficient, components of functional
sites within a biological sequence.
- Motifs are found in sites of post translational modifications, catalytic
or enzymatic activity and binding.
- Motifs within domains have included stretches of amino acids as short as
three residues RGD-cell adhesion to longer "regular expressions" that contain a pattern of usage although specific residues may vary.
- Motifs are derived from multiple sequence alignments.
Examples
BLOCKS: PlantGlobin Motif 1, 4-sequences
| Sequence ID |
Motif 1 width 18 residues |
|
NRL_1LH1
LGB4_MEDSA
LGB2_SESRO
LGB1_MEDSA
|
TESQAALVKSSWEEFNAN
TADQEALVNSSWESFKQN
TEKQEALVNASYEAFKQN
TDKQEALVNSSWEAFKQN
|
PROSITE (PS00016): Cell attachment sequence
R-G-D
PROSITE (PS00109):
Tyrosine protein kinase specific active-site signature
Pattern: [LIVMFYC]-x-[HY]-x-D-[LIVMFY]-[RSTAC]-x(2)-N-[LIVMFYC](3).
Example of protein (P12391)
containing this domain. Sequence within src protein fragment structure.
PROSITE (PDOC00005):
Protein kinase C phosphorylation site
PROSITE (PS00005):
PKC_PHOSPHO_SITE
Consensus pattern [ST]-x-[RK] [S or T is the phosphorylation site]
October 24, 2004